Virginia Byers Kraus, MD, PhD


Professor of Medicine
Associate Professor in Surgery
Professor of Pathology
Department / Division:
Medicine / Medicine-Rheumatology and Immunology
Address:
DUMC 3416
Durham, NC 27710
Appointment Telephone:
919-660-2399
Office Telephone:
919-681-6652
Fax:
919-684-8907
Training:
  • MD, Duke University School of Medicine, 1982
  • PhD, Microbiology and Immunology, Duke University School of Medicine, 1993
Residency:
  • Medicine, Duke University Medical Center, 1983-1986
Fellowship:
  • Rheumatology, Duke University Medical Center, 1986-1990
Clinical Interests:
Diagnosis, treatment and the study of hereditary forms of osteoarthritis; development of biomarkers for arthritis; clinical trials of new therapeutics for osteoarthritis
Research Interests:
My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.
Representative Publications:
  • Kraus, VB. Osteoarthritis year 2010 in review: biochemical markers. Osteoarthritis and Cartilage. 2011;19:346-353.  Abstract
  • Kraus, VB; Burnett, B; Coindreau, J; Cottrell, S; Eyre, D; Gendreau, M; Gardiner, J; Garnero, P; Hardin, J; Henrotin, Y; Heinegård, D; Ko, A; Lohmander, LS; Matthews, G; Menetski, J; Moskowitz, R; Persiani, S; Poole, AR; Rousseau, JC; Todman, M; OARSI FDA Osteoarthritis Biomarkers Working Group. Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis. Osteoarthritis and Cartilage. 2011;19:515-542.  Abstract
  • Pells, JJ; Shelby, RA; Keefe, FJ; Dixon, KE; Blumenthal, JA; Lacaille, L; Tucker, JM; Schmitt, D; Caldwell, DS; Kraus, VB. Arthritis self-efficacy and self-efficacy for resisting eating: relationships to pain, disability, and eating behavior in overweight and obese individuals with osteoarthritic knee pain. Pain. 2008;136:340-347.  Abstract
  • Allen, KD; DeVellis, RF; Renner, JB; Kraus, VB; Jordan, JM. Validity and factor structure of the AUSCAN Osteoarthritis Hand Index in a community-based sample. Osteoarthritis and Cartilage. 2007;15:830-836.  Abstract
  • Charles, HC; Kraus, VB; Ainslie, M; Hellio Le Graverand-Gastineau, MP. Optimization of the fixed-flexion knee radiograph. Osteoarthritis and Cartilage. 2007;15:1221-1224.  Abstract
  • Elliott, AL; Kraus, VB; Fang, F; Renner, JB; Schwartz, TA; Salazar, A; Huguenin, T; Hochberg, MC; Helmick, CG; Jordan, JM. Joint-specific hand symptoms and self-reported and performance-based functional status in African Americans and Caucasians: The Johnston County Osteoarthritis Project. Annals of the Rheumatic Diseases. 2007;66:1622-1626.  Abstract
  • Huebner, JL; Seifer, DR; Kraus, VB. A longitudinal analysis of serum cytokines in the Hartley guinea pig model of osteoarthritis. Osteoarthritis and Cartilage. 2007;15:354-356.  Abstract
  • Kraus, VB; Jordan, JM; Doherty, M; Wilson, AG; Moskowitz, R; Hochberg, M; Loeser, R; Hooper, M; Renner, JB; Crane, MM; Hastie, P; Sundseth, S; Atif, U. The Genetics of Generalized Osteoarthritis (GOGO) study: study design and evaluation of osteoarthritis phenotypes. Osteoarthritis and Cartilage. 2007;15:120-127.  Abstract
  • Kraus, VB; Stabler, TV; Kong, SY; Varju, G; McDaniel, G. Measurement of synovial fluid volume using urea. Osteoarthritis and Cartilage. 2007;15:1217-1220.  Abstract
  • Kraus, VB; Stabler, TV; Luta, G; Renner, JB; Dragomir, AD; Jordan, JM. Interpretation of serum C-reactive protein (CRP) levels for cardiovascular disease risk is complicated by race, pulmonary disease, body mass index, gender, and osteoarthritis. Osteoarthritis and Cartilage. 2007;15:966-971.  Abstract
  • Shamji, MF; Betre, H; Kraus, VB; Chen, J; Chilkoti, A; Pichika, R; Masuda, K; Setton, LA. Development and characterization of a fusion protein between thermally responsive elastin-like polypeptide and interleukin-1 receptor antagonist: sustained release of a local antiinflammatory therapeutic. Arthritis and Rheumatism. 2007;56:3650-3661.  Abstract
  • Bauer, DC; Hunter, DJ; Abramson, SB; Attur, M; Corr, M; Felson, D; Heinegård, D; Jordan, JM; Kepler, TB; Lane, NE; Saxne, T; Tyree, B; Kraus, VB; Osteoarthritis Biomarkers Network. Classification of osteoarthritis biomarkers: a proposed approach. Osteoarthritis and Cartilage. 2006;14:723-727.  Abstract
  • Huebner, JL; Kraus, VB. Assessment of the utility of biomarkers of osteoarthritis in the guinea pig. Osteoarthritis and Cartilage. 2006;14:923-930.  Abstract
  • Kong, SY; Stabler, TV; Criscione, LG; Elliott, AL; Jordan, JM; Kraus, VB. Diurnal variation of serum and urine biomarkers in patients with radiographic knee osteoarthritis. Arthritis and Rheumatism. 2006;54:2496-2504.  Abstract
  • Kraus, VB. Do biochemical markers have a role in osteoarthritis diagnosis and treatment?. Best Practice and Research: Clinical Rheumatology. 2006;20:69-80.  Abstract
  • Criscione, LG; Elliott, AL; Stabler, T; Jordan, JM; Pieper, CF; Kraus, VB. Variation of serum hyaluronan with activity in individuals with knee osteoarthritis. Osteoarthritis and Cartilage. 2005;13:837-840.  Abstract
  • Clark, AG; Rohrbaugh, AL; Otterness, I; Kraus, VB. The effects of ascorbic acid on cartilage metabolism in guinea pig articular cartilage explants. Matrix Biology. 2002;21:175-184.  Abstract
  • Huebner, JL; Hanes, MA; Beekman, B; TeKoppele, JM; Kraus, VB. A comparative analysis of bone and cartilage metabolism in two strains of guinea-pig with varying degrees of naturally occurring osteoarthritis. Osteoarthritis and Cartilage. 2002;10:758-767.  Abstract
  • Kraus, VB; Huebner, JL; Fink, C; King, JB; Brown, S; Vail, TP; Guilak, F. Urea as a passive transport marker for arthritis biomarker studies. Arthritis and Rheumatism. 2002;46:420-427.  Abstract
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