David Stephen Pisetsky, MD, PhD

Professor of Medicine
Professor of Immunology
Department / Division:
Medicine / Medicine-Rheumatology and Immunology
DUMC 3544
Durham, NC 27710
Appointment Telephone:
Not accepting new patients
Office Telephone:
  • MD, PhD, Albert Einstein College of Medicine of Yeshiva University (New York), 1973
  • Medicine, Yale-New Haven Hospital (Connecticut), 1973-1975
  • Immunology, National Institutes of Health (Maryland), 1975-1978
Clinical Interests:
Rheumatoid arthritis, systemic lupus erythematosus, general rheumatology
Representative Publications:
  • Rutledge, HR; Jiang, W; Yang, J; Warg, LA; Schwartz, DA; Pisetsky, DS; Yang, IV. Gene expression profiles of RAW264.7 macrophages stimulated with preparations of LPS differing in isolation and purity. Innate immunity. 2012;18:80-88.  Abstract
  • Distler, JH; Akhmetshina, A; Dees, C; Jüngel, A; Stürzl, M; Gay, S; Pisetsky, DS; Schett, G; Distler, O. Induction of apoptosis in circulating angiogenic cells by microparticles. Arthritis and Rheumatism. 2011;63:2067-2077.  Abstract
  • Pisetsky, DS. Platelet microparticles: making blood a bad humor. Journal of Rheumatology. 2011;38:590-592.  Abstract
  • Pisetsky, DS; Gauley, J; Ullal, AJ. Microparticles as a source of extracellular DNA. Immunologic Research: a selective reference to current research and practice. 2011;49:227-234.  Abstract
  • Ullal, AJ; Reich, CF; Clowse, M; Criscione-Schreiber, LG; Tochacek, M; Monestier, M; Pisetsky, DS. Microparticles as antigenic targets of antibodies to DNA and nucleosomes in systemic lupus erythematosus. Journal of Autoimmunity. 2011;36:173-180.  Abstract
  • Beyer, C; Pisetsky, DS. The role of microparticles in the pathogenesis of rheumatic diseases. Nature Reviews. Rheumatology. 2010;6:21-29.  Abstract
  • Gauley, J; Pisetsky, DS. The release of microparticles by RAW 264.7 macrophage cells stimulated with TLR ligands. Journal of Leukocyte Biology. 2010;87:1115-1123.  Abstract
  • Grundtman, C; Bruton, J; Yamada, T; Ostberg, T; Pisetsky, DS; Harris, HE; Andersson, U; Lundberg, IE; Westerblad, H. Effects of HMGB1 on in vitro responses of isolated muscle fibers and functional aspects in skeletal muscles of idiopathic inflammatory myopathies. The FASEB Journal. 2010;24:570-578.  Abstract
  • Pisetsky, DS. Charlie's List. Annals of Internal Medicine. 2010;153:344.  Abstract
  • Pisetsky, DS. HMGB1: a dangerous player in lupus pathogenesis. Journal of Rheumatology. 2010;37:689-691.  Abstract
  • Pisetsky, DS. The role of HMGB1 in efferocytosis: when the dead go unburied. Focus on "HMGB1 inhibits macrophage activity in efferocytosis through binding to the alphavbeta3-integrin". American Journal of Physiology: Cell Physiology. 2010;299:C1253-C1255.  Abstract
  • Pisetsky, DS; Lipsky, PE. Microparticles as autoadjuvants in the pathogenesis of SLE. Nature Reviews. Rheumatology. 2010;6:368-372.  Abstract
  • Pisetsky, DS; Ullal, AJ. The blood nucleome in the pathogenesis of SLE. Autoimmunity Reviews. 2010;10:35-37.  Abstract
  • Ullal, AJ; Pisetsky, DS. The release of microparticles by Jurkat leukemia T cells treated with staurosporine and related kinase inhibitors to induce apoptosis. Apoptosis: an international journal on programmed cell death. 2010;15:586-596.  Abstract
  • Ullal, AJ; Pisetsky, DS; Reich, CF. Use of SYTO 13, a fluorescent dye binding nucleic acids, for the detection of microparticles in in vitro systems. Cytometry Part A. 2010;77:294-301.  Abstract
  • Crowley, SD; Vasievich, MP; Ruiz, P; Gould, SK; Parsons, KK; Pazmino, AK; Facemire, C; Chen, BJ; Kim, HS; Tran, TT; Pisetsky, DS; Barisoni, L; Prieto-Carrasquero, MC; Jeansson, M; Foster, MH; Coffman, TM. Glomerular type 1 angiotensin receptors augment kidney injury and inflammation in murine autoimmune nephritis. Journal of Clinical Investigation. 2009;119:943-953.  Abstract
  • Gauley, J; Pisetsky, DS. The translocation of HMGB1 during cell activation and cell death. Autoimmunity. 2009;42:299-301.  Abstract
  • Pisetsky, DS. Microparticles as biomarkers in autoimmunity: from dust bin to center stage. Arthritis Research and Therapy. 2009;11:135.  Abstract
  • Pisetsky, DS; Rönnblom, L. Systemic lupus erythematosus: a matter of life and death. Arthritis and Rheumatism. 2009;60:1567-1570.  Abstract
  • Pisetsky, DS; Vrabie, IA. Antibodies to DNA: infection or genetics?. Lupus. 2009;18:1176-1180.  Abstract
  • Reich, CF; Pisetsky, DS. The content of DNA and RNA in microparticles released by Jurkat and HL-60 cells undergoing in vitro apoptosis. Experimental Cell Research. 2009;315:760-768.  Abstract
  • Su, KY; Pisetsky, DS. The role of extracellular DNA in autoimmunity in SLE. Scandinavian Journal of Immunology. 2009;70:175-183.  Abstract
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